Causes Of Uterine Cancer

Like other types of cancers, the leading cause of uterine cancer is currently unknown. However, there are several factors that experts believe to increase the possibility of uterine cancer. Some of the major risk factors for uterine Cancer include:

Changes In The DNA

Uterine cancer can be due to variations in the DNA of a standard cell found in the uterine. The primary changes may result from mutations that activate oncogenes or deactivate tumor suppressor genes. Furthermore, these variations in the DNA can happen to a person during their lifetime or they could inherit it from their parents.

Two types of DNA gene mutations are:

  • Inherited gene mutations: Some inherited genes from the parents tend to increase the risk of uterine cancer. However, inherited gene mutations are a lesser cause of Uterine cancer.
  • Acquired gene mutations: These, on the other hand, are mutations that happen during a one’s lifetime and not due to inheritable genes. Furthermore, these are changes that are only present in the cells that come from the original cancerous cell.

Uterine Cancer Risk Factors

Having any of the risk factors for uterine cancer does not immediately mean that you will get the disease. However, they can increase your chances of getting it. There are several risk factors that may increase your danger of getting uterine cancer such as:

The Patient’s Age

Uterine cancer is more common in older people than younger people below the age of 40. Furthermore, the chances of someone developing uterine cancer increases after age 55. (1)

Family History

Having a family member who has a history of uterine cancer increases the risk of developing the disease. This risk is greater the closer your relationship is to your relative. Furthermore, having a family member with uterine cancer can also increase your risk not just because of the genes you share, but also due to the same environment you are exposed to.

A Person’s Race

Uterine cancer is more common in African-American women than in white or Asian women. This may be contributed to the varying conditions or genes that each race has. (2)

Pelvic Radiation Therapy

Ironically, radiation used to treat different types of cancer may in itself cause cancer.  Studies have shown that those who have had pelvic radiation tend to have a higher risk of developing uterine cancers. Furthermore, the reoccurrence of cancer due to radiation treatment may take up to 5 to 25 years to redevelop.

Changes In The RB Gene

Those women who have had retinoblastoma, a type of eye cancer that caused by being born with an abnormal copy of the RB gene, also have a higher risk of developing uterine leiomyosarcomas.

History Of Smoking

Smoking is a major uterine cancer risk factors. Furthermore, it increases the risk of developing cancer of the uterus. The risk is related to how much one smokes and the risk drops if you stop smoking.

History Of Obesity

Being very overweight increases the risk of developing uterine cancer as a result of a fatty uterine disease.

History Of Birth Control Pill Usage

Women who use contraceptives also known as birth control pills have a higher risk of uterine cancer. Nevertheless, the risk may decrease after 3 to 6 months of using the pill. (3)

History Of Breast Cancer

If you happen to have had breast cancer before, this may lead to a higher risk of uterine cancer. Some of the risks of reproduction for uterine cancer may also interfere with breast cancer risk.

History Of Androgen Use

Androgens are male hormones, and the main androgen is danazol (a drug that increases the androgen levels). Women who have taken danazol have a higher risk of uterine cancer

However, having one or many of these uterine kidney cancer risk factors does not indicate that one will develop cancer of the uterus but it is important to note these factors are related to the development of uterine cancer.


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